MDM(+)-mediated enhancement of neuronal IA in a MDM-neuronal co-culture system. MDM(+) or non-stimulated MDM [MDM(-)] were added to neuronal cultures 24 h prior to the recording. Current traces were recorded from four different neurons with different treatments: (A) control (Ctrl), (B) co-cultured with LPS-stimulated MDM (MDM+), (C) co-cultured with non-stimulated MDM (MDM-) and (D) cultured with MCM+. Compared with control, an increase of IA was recorded in neurons co-cultured with MDM+, MDM- and MCM+, respectively (E). Note the strongest effect was produced by MDM+. * p≤0.0001 vs Ctrl, # p=0.03 vs Ctrl.