Figure 6.
Heating denature of the proteins by boiling the MCM(+) for 15 min failed to abolish the effect of MCM(+) on neuronal IA. Panel A is the exemplary current traces recorded from hippocampal neurons before (Ctrl), during (boiled MCM+) and after (wash) bath application of the boiled MCM(+). Panel B is the bar graph illustrating the average IA current densities. Note that denature of MCM+ proteins failed to prevent MCM(+)-induced enhancement of neuronal current. * p=0.018 vs Ctrl, # p≤0.0001 vs Ctrl.