Brm loss induces hyperplasia of the prostatic epithelia. A, the proliferative indices of Brm+/+ and Brm−/− littermates were determined in unchallenged 6-month-old animals by immunostaining for Ki67. At least 1,000 cells were tallied per animal by a blinded observer for each AP and VP. In the DLP, at least 500 cells were scored per animal, due to the small size of this lobe. Averages, SD, and n numbers are as indicated. A representative example of the AP is provided (bottom). B, lobes in A were processed to detect apoptotic indices by TUNEL staining.