TABLE 1.
Peripheral white blood cell count (WBC) and free radical-producing capacity of polymorphonuclear granulocytes (PMNs) in dogs subjected to experimental ischemia and reperfusion and in sham-operated controls
| WBC (×109 cells/L) | PMNs (nmol O2-./min/106 PMN) | |||
|---|---|---|---|---|
| LAD ligature (60 min) | Sham | LAD ligature (60 min) | Sham | |
| Before thoracotomy | 6.9±0.7 | 6.6±1.3 | 15.6±2.9 | 13.4±2.7 |
| LAD ligature (60 min) | 7.0±1.2 | 6.0±1.2 | 13.9±3.1 | 10.8±2.0 |
| Reperfusion | ||||
| 5 min | 7.5±1.0 | 11.6±2.3 | ||
| 60 min | 8.0±0.6 | 6.5±1.0 | 12.4±1.5 | 10.2±1.8 |
| 1 day | 32.3±5.2** | 27.9±1.6*** | 17.1±3.1 | 14.1±1.0 |
| 2 days | 30.1±2.0*** | 19.8±1.3*** | 14.2±4.2 | 11.5±0.4 |
| 3 days | 22.6±3.4* | 18.9±1.3** | 7.7±1.8* | 7.2±1.1 |
| 7 days | 19.4±2.7* | 16.6±0.7** | 14.8±2.2 | 9.5±3.1 |
| 14 days | 14.8±0.8*** | 17.2±1.9* | 13.7±1.8 | 9.6±2.7 |
| 21 days | 14.7±2.1* | 12.3±1.1 | 17.1±2.6 | 9.9±2.7 |
| 28 days | 17.3±2.6* | 10.8±0.7* | 18.4±3.9 | 10.1±1.8 |
*
P<0.05,
**
P<0.02,
***
P<0.01 versus before thoracotomy. LAD Left anterior descending coronary artery