Table 1.

Binding sites detection with a structural similarity mapping method, evolutionary conservation mapping method and an energy-based method on a set of 39 proteins

Method	Total no. of residues	Interface no. residues	No. of predicted residues	P-value (× 10−3)	SP (%)	SE (%)
ProBiSa	224	54	62.8	1.4	39.0	43.9
ConSurfb	224	54	60.6	33.0	34.3	38.1
Q-SiteFinder	224	54	48.5	6.5	39.4	38.2

Tables with detailed results are available in the Supplementary Material.

^aThe alignment scores listed in the ‘Methods’ section were used.

^bConSurf uses different methods to count conserved residues. We used the Bayesian method which is enabled by default and gives the best results.