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Confocal microscopy images of HeLa cells after 18 h incubation in the presence of 5 µM compound. Nocodazole is a known tubulin polymerization inhibitor. Nuclear DNA was stained with propidium iodide (red channel) and tubulin was stained with FITC-conjugated anti-α-tubulin antibody (green channel). Compounds 4e and 13e disrupted normal microtubule structures, caused fragmentation of mitotic spindles, and induced M-phase arrest.
