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. Author manuscript; available in PMC: 2011 Apr 22.
Published in final edited form as: J Med Chem. 2010 Apr 22;53(8):3389–3395. doi: 10.1021/jm1000979

Chart 1.

Chart 1

Structures of anti-tuberculosis compounds 2 and 3 and antimicrotubule compound 4e, all derived from a fragment of mycobactin S (1). MIC values indicate in vitro anti-tuberculosis activity against M. tuberculosis H37Rv in GAST medium21, and IC50 values indicate in vitro antiproliferative activity against human breast cancer cell line MCF-7.