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. Author manuscript; available in PMC: 2011 Apr 22.
Published in final edited form as: J Med Chem. 2010 Apr 22;53(8):3389–3395. doi: 10.1021/jm1000979

Table 2.

Antiproliferative activities (IC50) of compounds 4e, 13a–f, 14, colchicine, and 2-methoxyestradiol against human breast cancer cell line MCF-7 and human lymphoma cell line U937.

graphic file with name nihms191217t2.jpg
Compound R2 IC50 (µM)a
MCF-7 U937
4e graphic file with name nihms191217t3.jpg 0.56 ± 0.11 1.40 ± 0.18
13a graphic file with name nihms191217t4.jpg 0.33 ± 0.045 1.13 ± 0.44
13b graphic file with name nihms191217t5.jpg 1.9 ± 1.4 nd
13c graphic file with name nihms191217t6.jpg 0.66 ± 0.31 3.75 ± 1.78
13d graphic file with name nihms191217t7.jpg 0.64 ± 0.35 2.19 ± 0.58
13e graphic file with name nihms191217t8.jpg 0.046 ±
0.022		 0.58 ± 0.42
13f graphic file with name nihms191217t9.jpg 0.245 ± 0.007 nd
14 graphic file with name nihms191217t10.jpg 6.4 ± 1.3 28 ± 19
Colchicine 0.0134 0.008 ± 0.003
2-methoxyestradiol 0.842 ± 0.090 2.91 ± 1.17
a

IC50 values represent the concentration at which the cell count was inhibited to 50% of that measured in the vehicle control. Error is S.E.M., n≥3.