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. Author manuscript; available in PMC: 2011 Apr 22.
Published in final edited form as: J Med Chem. 2010 Apr 22;53(8):3389–3395. doi: 10.1021/jm1000979

Table 5.

Standard COMPARE analysis of 4e. The Target Set was the Standard Agent Database and the Target Set Endpoints were set equal to the Seed Endpoints (GI50, TGI, and LC50). Correlation values (r) are Pearson’s correlation coefficients. Some hits appear multiple times because they were tested by the NCI for the Standard Agent Database at multiple concentration ranges.

rank compound r
Based on GI50 Mean Graph
     1 paclitaxel 0.541
     2 maytansine 0.534
     3 vincristine sulfate 0.500
     4 trimetrexate 0.480
     5 soluble Baker's Antifol 0.460
Based on TGI Mean Graph
     1 paclitaxel (hiConc = 10−5 M) 0.654
     2 paclitaxel (hiConc = 10−6 M) 0.646
     3 paclitaxel (hiConc = 10−4.6 M) 0.642
     4 maytansine 0.621
     5 vinblastine sulfate 0.606
Based on LG50 Mean Graph
     1 rhizoxin (hiConc = 10−9 M) 0.681
     2 rhizoxin (hiConc = 10−4 M) 0.650
     3 vinblastine sulfate (hiConc = 10−7.6 M) 0.558
     4 α-2'-deoxythioguanosine 0.545
     5 vinblastine sulfate (hiConc = 10−4 M) 0.540