Table 3.

Associations of SNPs in IL6 with rate of decline of FEV1 in the LHS and association with COPD in the NETT-NAS

			LD (r2 with rs1800795)		Rate of FEV1 decline study in the LHS				COPD case control study in the NETT-NAS
Bin	SNP ID	SNP in gene	LHS	NETT-NAS	Fast decline MAF %	Non-decline MAF %	p-value‡ genotype based	p-value‡ additive	NETT MAF %	NAS MAF %	p-value§ genotype based	p-value§ additive
1	rs1800797†	−598G/A	NA	0.93					0.41	0.35	0.06	0.02
1	rs1800795*†	−174G/C	-	-	0.45	0.40	0.006	0.041	0.42	0.36	0.03	0.01
1	rs2069832†	615A/G	NA	0.98					0.42	0.37	0.1	0.09
1	rs1474348†	1090G/C	NA	0.97					0.41	0.36	0.1	0.04
1	rs1474347†	1306G/T	NA	0.98					0.42	0.36	0.06	0.03
2	rs1554606*†	1889G/T	0.84	0.87	0.47	0.43	0.011	0.103	0.44	0.38	0.02	0.01
2	rs2069845*	3331G/A	0.89	NA	0.47	0.42	0.007	0.078
3	rs2069825*	−1479CT/−	0.90	NA	0.44	0.37	< 0.001	0.023
4	rs2069840*†	1754C/G	0.36	0.33	0.32	0.37	0.005	0.064	0.35	0.36	0.3	0.7
5	rs1818879*	5909G/A	0.32	NA	0.29	0.34	0.012	0.035
6	rs2069827*†	−1363G/T	0.12	0.14	0.08	0.08	0.786∥	0.669	0.09	0.09	0.9	0.4
other	rs2069849†	4338C/T	NA	0.02					0.03	0.02	0.2	0.2

^*Genotyped in the LHS,

^†Genotyped in the NETT-NAS

^‡Adjustment for confounding factors such as age, gender, pack-years of smoking, and research center.

^§As the NAS controls were uniformly male smokers with normal lung function, the models were adjusted for age and pack-years.

^∥The p values were from a dominant genetic model because the minor allele frequency of this SNP was very low.