Table 4.
Association of serum concentrations of IL6 and IL6 genotypes (linear regression*)
| SNP | Genotype | IL6 level [ln IL6 (pg/ml)] |
||
|---|---|---|---|---|
| N | Coefficient (SE) | p value | ||
| II | 514 | |||
| IL6_−1479 | ID | 681 | −0.011 (0.046) | |
| (rs2069825) | DD | 229 | −0.080 (0.063) | 0.424† |
|
| ||||
| IL6_−1363 | GG | 1185 | ||
| (rs2069827) | GT+TT | 234 | 0.000 (0.057) | 0.997† |
|
| ||||
| GG | 483 | |||
| IL6_−174 | GC | 691 | 0.013 (0.047) | |
| (rs 1800795) | CC | 255 | −0.056 (0.061) | 0.486† |
|
| ||||
| CC | 234 | |||
|
| ||||
| IL6_1754 | CG | 234 | 0.000 (0.048) | |
|
| ||||
| (rs2069840) | GG | 72 | −0.030 (0.064) | 0.820‡ |
|
| ||||
| GG | 169 | |||
|
| ||||
| IL6_1889 | GT | 261 | 0.013 (0.044) | |
|
| ||||
| (rs 1554606) | TT | 110 | −0.057 (0.054) | 0.542‡ |
|
| ||||
| AA | 431 | |||
| IL6_3331 | AG | 689 | 0.015 (0.049) | |
| (rs2069845) | GG | 293 | −0.020 (0.060) | 0.819† |
|
| ||||
| AA | 685 | |||
| IL6_5909 | AG | 593 | 0.012 (0.044) | |
| (rs1818879) | GG | 137 | −0.025 (0.074) | 0.877† |
*
P values were from genotype-based analysis (co-dominant genetic models) except for IL6_−1363 where p values were from a dominant genetic model because the minor allele frequency for this SNP was very low.
†
Adjusted for BMI, age, gender, pack years of smoking, and smoking status;
‡
Adjusted for BMI, age, gender, pack years of smoking.