Figure 1. Pedigrees and clinical features of two Guyanese families with ARWH.
(a) Pedigree of Family A. (b) Clinical features of the affected individuals II-1 (left) and II-2 (right) in Family A when they were 12 and 10 years old, respectively. Note that both showed an obvious woolly hair phenotype. (c) Present clinical features of the affected individual II-1 in Family A. (d, e) Under light microscopy, hair shafts of the affected individual II-1 in Family A show twisting (d) and a tapered end (e). Scale bars: 100 μm. (f) Pedigree of Family B. (g, h) Hair phenotypes of the affected individuals in Family B. The affected individual II-1 show sparse and tightly curled hair (g), while the affected individual II-3 shows sparse and mildly wavy hair (h). (i) Diffuse keratotic follicular papules on legs of the affected individual II-1 in Family B.