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LRRK2 increases JIP levels but does not induce translocation. HEK 293 cells were transfected with Flag-tagged JIP1–3 ± V5-LRRK2 or Flag-tagged JIP4 ± V5-LRRK2. The resulting lysates were separated into cytoplasmic (upper panel) or membrane (lower panel) components. Cotransfecting LRRK2 increased JIP levels in both the cytoplasmic and membrane fractions equally. Representative data from three independent experiments.
