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LRRK2 increases JIP ubiquitination. HEK 293 cells were transfected with Flag-tagged JIP1–3, V5-LRRK2 ± HA ubiquitin. The lysates were subjected to immunoprecipitation with anti-Flag antibody, and probed with antibodies to V5 (for LRRK2), HA (for ubiquitin) or Flag (for JIP4). Cotransfection increased oligomerization of JIP4, and resulted in immunoprecipitation (IP) of ubiquitinated JIP4. Representative data from three independent experiments.
