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Disease-linked mutations in LRRK2 increase JIP oligomerization. HEK 293 cells were transfected with Flag-tagged JIP1–3, V5-LRRK2 (WT, G2019S, R1441C, I2020T or Y1699C) ± HA ubiquitin. JIP4 was immunoprecipitated (a) and the amount of oligomeric JIP4 quantified (b). a The arrow points to the oligomer bands used for quantification, and quantification was relative to total JIP4 levels. b ∗ p ≤ 0.05 (n = 3).
