TABLE II. Haplotype-Based Association Results in the Family Sample.
Block | SNPs | Allele | FBAT | PDT | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Freq | Z | P | S | E (S) | Global, P | Freq | Z | P | Trio-T | Trio-NT | Aff Sib | Unaff Sib | Global, P | |||
Narrow | ||||||||||||||||
1 | 6–7 | 1-1 | 0.68 | 0.40 | 0.69 | 294.97 | 292.44 | 0.395 | 0.65 | −0.38 | 0.70 | 68 | 58 | 635 | 656 | 0.606 |
1-2 | 0.27 | 0.37 | 0.71 | 170.03 | 167.99 | 0.33 | 0.66 | 0.51 | 24 | 28 | 292 | 270 | ||||
2-2 | 0.045 | −1.33 | 0.18 | 34.97 | 39.53 | 0.02 | −0.96 | 0.34 | 4 | 10 | 17 | 18 | ||||
2 | 8–9 | 1-1 | 0.32 | 1.05 | 0.29 | 191 | 184.23 | 0.366 | 0.38 | 0.00 | 1.00 | 35 | 37 | 259 | 257 | 0.728 |
1-2 | 0.42 | 0.21 | 0.83 | 243 | 241.53 | 0.39 | 0.51 | 0.61 | 44 | 46 | 266 | 249 | ||||
2-1 | 0.26 | −1.30 | 0.19 | 156 | 164.25 | 0.22 | −0.83 | 0.40 | 25 | 21 | 157 | 176 | ||||
3 | 10–11 | 1-1 | 0.11 | 1.43 | 0.15 | 82.03 | 74.87 | 0.114 | 0.12 | 1.28 | 0.20 | 13 | 11 | 134 | 110 | 0.237 |
1-2 | 0.42 | −2.01 | 0.04 | 198.97 | 213.35 | 0.41 | −1.51 | 0.13 | 36 | 46 | 371 | 402 | ||||
2-1 | 0.46 | 1.19 | 0.23 | 250.97 | 242.72 | 0.47 | 0.64 | 0.52 | 53 | 44 | 503 | 496 | ||||
4 | 12–13 | 1-1 | 0.56 | 1.40 | 0.16 | 292.89 | 282.30 | 0.267 | 0.53 | 0.97 | 0.33 | 72.98 | 62.97 | 651.4 | 631.4 | 0.459 |
2-1 | 0.34 | −0.64 | 0.53 | 207.11 | 211.50 | 0.35 | −1.00 | 0.32 | 43.02 | 49.03 | 420.6 | 443.6 | ||||
2-2 | 0.10 | −1.35 | 0.18 | 74.89 | 81.08 | 0.12 | −0.64 | 0.53 | 9.982 | 15.97 | 162.4 | 169.4 | ||||
5 | 15–16 | 1-1 | 0.51 | 2.82 | 0.0048 | 295.97 | 275.66 | 0.045 | 0.51 | 2.48 | 0.01 | 51 | 35 | 555 | 513 | 0.019 |
2-2 | 0.46 | −2.58 | 0.0098 | 231.97 | 251.26 | 0.46 | −2.18 | 0.03 | 46 | 59 | 414 | 457 | ||||
Intermediate | ||||||||||||||||
1 | 6–7 | 1-1 | 0.68 | −0.76 | 0.45 | 351.97 | 356.682 | 0.280 | 0.65 | −1.11 | 0.27 | 81 | 71 | 681 | 722 | 0.26 |
1-2 | 0.27 | 1.43 | 0.15 | 209.04 | 201.24 | 0.33 | 1.41 | 0.16 | 29 | 33 | 334 | 292 | ||||
2-2 | 0.05 | −0.85 | 0.39 | 44.97 | 48.032 | 0.02 | −0.91 | 0.36 | 4 | 10 | 19 | 20 | ||||
2 | 8–9 | 1-1 | 0.32 | 2.12 | 0.0344 | 232.00 | 218.43 | 0.0496 | 0.38 | 1.13 | 0.26 | 49 | 49 | 310 | 286 | 0.38 |
1-2 | 0.42 | −0.16 | 0.87 | 288.00 | 289.11 | 0.39 | 0.04 | 0.97 | 54 | 54 | 271 | 270 | ||||
2-1 | 0.26 | −1.98 | 0.0475 | 190.00 | 202.46 | 0.22 | −1.27 | 0.20 | 29 | 29 | 173 | 198 | ||||
3 | 10–11 | 1-1 | 0.11 | 1.54 | 0.12 | 101.09 | 93.16 | 0.0437 | 0.12 | 1.62 | 0.11 | 17 | 15 | 150 | 121 | 0.06308 |
1-2 | 0.42 | −2.40 | 0.0163 | 254.91 | 272.69 | 0.41 | −2.12 | 0.0337 | 41 | 54 | 385 | 432 | ||||
2-1 | 0.46 | 1.51 | 0.13 | 297.91 | 286.78 | 0.47 | 1.08 | 0.28 | 60 | 48 | 565 | 547 | ||||
4 | 12–13 | 1-1 | 0.56 | 2.12 | 0.0342 | 353.89 | 337.40 | 0.0504 | 0.53 | 1.65 | 0.0982 | 92.96 | 82.97 | 721.3 | 678.4 | 0.13 |
2-1 | 0.34 | −1.06 | 0.29 | 247.11 | 254.93 | 0.35 | −1.73 | 0.0834 | 48.04 | 58.03 | 431.7 | 474.6 | ||||
2-2 | 0.10 | −1.92 | 0.0544 | 91.89 | 100.54 | 0.12 | −0.69 | 0.49 | 16.96 | 18.97 | 169.3 | 179.4 | ||||
5 | 15–16 | 1-1 | 0.51 | 2.81 | 0.0050 | 344.94 | 324.10 | 0.0433 | 0.51 | 2.91 | 0.0036 | 58 | 39 | 608 | 553.9 | 0.00613 |
2-2 | 0.46 | −2.60 | 0.0093 | 290.94 | 310.74 | 0.46 | −0.37 | 0.71 | 1 | 0.0000 | 8.047 | 4.052 | ||||
Broad | ||||||||||||||||
1 | 6–7 | 1-1 | 0.68 | −0.61 | 0.54 | 379.94 | 384.143 | 0.178 | 0.65 | −0.90 | 0.37 | 83 | 74 | 671 | 709 | 0.30 |
1-2 | 0.27 | 1.54 | 0.12 | 225.06 | 216.171 | 0.33 | 1.28 | 0.20 | 30 | 34 | 330 | 287 | ||||
2-2 | 0.05 | −1.14 | 0.26 | 46.94 | 51.626 | 0.02 | −1.09 | 0.28 | 5 | 10 | 19 | 24 | ||||
2 | 8–9 | 1-1 | 0.32 | 2.09 | 0.0366 | 254 | 239.25 | 0.067 | 0.38 | 0.91 | 0.36 | 52 | 52 | 285 | 264 | 0.58 |
1-2 | 0.42 | −0.32 | 0.75 | 308 | 310.24 | 0.39 | −0.10 | 0.92 | 55 | 55 | 258 | 261 | ||||
2-1 | 0.26 | −1.87 | 0.0615 | 202 | 214.51 | 0.22 | −0.90 | 0.37 | 29 | 29 | 167 | 185 | ||||
3 | 10–11 | 1-1 | 0.11 | 1.11 | 0.27 | 105.15 | 99.66 | 0.122 | 0.12 | 1.00 | 0.32 | 18 | 16 | 141 | 123 | 0.23 |
1-2 | 0.42 | −1.90 | 0.0572 | 274.85 | 290.33 | 0.41 | −1.59 | 0.11 | 44 | 54 | 376 | 415 | ||||
2-1 | 0.46 | 1.33 | 0.18 | 317.85 | 306.62 | 0.47 | 0.93 | 0.35 | 60 | 51 | 577 | 556 | ||||
4 | 12–13 | 1-1 | 0.56 | 1.37 | 0.17 | 380.86 | 369.54 | 0.190 | 0.53 | 1.07 | 0.28 | 95.96 | 87.97 | 701.3 | 673.4 | 0.38 |
2-1 | 0.34 | −0.50 | 0.61 | 272.14 | 276.03 | 0.35 | −1.16 | 0.25 | 50.04 | 59.03 | 427.7 | 455.6 | ||||
2-2 | 0.10 | −1.64 | 0.10 | 99.86 | 107.28 | 0.12 | −0.67 | 0.51 | 17.96 | 18.97 | 165.3 | 175.4 | ||||
5 | 15–16 | 1-1 | 0.51 | 2.88 | 0.0040 | 369.93 | 346.61 | 0.0231 | 0.51 | 3.14 | 0.0017 | 59 | 42 | 613 | 543.9 | 0.00359 |
2-2 | 0.46 | −2.55 | 0.0109 | 308.93 | 329.99 | 0.46 | −2.67 | 0.0076 | 55 | 69 | 418 | 481.9 | ||||
Very broad | ||||||||||||||||
1 | 6–7 | 1-1 | 0.68 | −0.12 | 0.91 | 496.94 | 497.69 | 0.228 | 0.65 | −0.45 | 0.65 | 110 | 101 | 552 | 572 | 0.19 |
1-2 | 0.27 | 1.28 | 0.20 | 281.06 | 273.40 | 0.33 | 1.23 | 0.22 | 41 | 42 | 261 | 231 | ||||
2-2 | 0.05 | −1.47 | 0.14 | 55.94 | 62.84 | 0.02 | −1.80 | 0.0719 | 5 | 13 | 13 | 23 | ||||
2 | 8–9 | 1-1 | 0.32 | 2.03 | 0.0421 | 320 | 306.11 | 0.103 | 0.38 | 1.38 | 0.17 | 70 | 66 | 248 | 224 | 0.38 |
1-2 | 0.42 | −0.65 | 0.51 | 398 | 402.86 | 0.39 | −0.79 | 0.43 | 77 | 79 | 225 | 240 | ||||
2-1 | 0.26 | −1.38 | 0.17 | 268 | 277.03 | 0.22 | −0.62 | 0.53 | 41 | 43 | 145 | 154 | ||||
3 | 10–11 | 1-1 | 0.11 | 0.83 | 0.41 | 131.25 | 126.99 | 0.0624 | 0.12 | 0.52 | 0.60 | 22 | 23 | 101 | 93.01 | 0.19 |
1-2 | 0.42 | −2.25 | 0.0243 | 342.75 | 360.86 | 0.41 | −1.66 | 0.0974 | 57 | 73 | 325 | 352 | ||||
2-1 | 0.46 | 1.82 | 0.0687 | 409.75 | 394.28 | 0.47 | 1.42 | 0.15 | 79 | 61 | 440 | 421 | ||||
4 | 12–13 | 1-1 | 0.56 | 1.53 | 0.13 | 495.86 | 482.79 | 0.0932 | 0.53 | 0.89 | 0.37 | 125.9 | 115 | 570.5 | 556.5 | 0.47 |
2-1 | 0.34 | −0.31 | 0.75 | 364.14 | 366.69 | 0.35 | −0.72 | 0.47 | 73.05 | 81.04 | 378.5 | 389.5 | ||||
2-2 | 0.10 | −2.06 | 0.0390 | 134.86 | 144.88 | 0.12 | −0.97 | 0.33 | 28.95 | 33.96 | 137.5 | 147.5 | ||||
5 | 15–16 | 1-1 | 0.51 | 2.79 | 0.0053 | 463.87 | 439.45 | 0.0392 | 0.51 | 2.69 | 0.0071 | 75 | 51 | 486 | 443 | 0.00916 |
2-2 | 0.46 | −2.66 | 0.0079 | 389.87 | 413.27 | 0.46 | −2.52 | 0.0119 | 71 | 94 | 366 | 410 |