Table 2.
Comparison of DTNBP1 high-risk haplotype in the Irish study and the HapMap samples
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1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | Frequency |
|||
---|---|---|---|---|---|---|---|---|---|---|---|---|
ISHDSF | CEU | JPT+CHB | YRI | |||||||||
Marmost | A | T | G | C | G | A | G | G | ||||
Rhesus | . | C | . | G | A | . | . | . | ||||
Orangutan | . | C | . | . | . | . | . | . | ||||
Chimp | . | C | . | A | . | . | . | A | ||||
1 | . | C | T | . | . | G | . | A | 0.733 | 0.750 | 0.705 | 0.633 |
2 | G | C | . | T | A | . | . | . | 0.058 | 0.108 | 0.005 | 0.025 |
3 | . | C | T | . | . | G | A | A | 0.071 | 0.058 | 0.211 | |
4 | . | C | T | T | . | G | . | A | 0.010 | |||
5 | G | . | . | T | A | . | . | A | 0.060 | 0.075 | 0.072 | 0.308 |
6 | G | C | T | T | . | G | A | . | 0.015 | 0.008 | ||
Rare | G | . | . | T | A | . | A | . |
Abbreviations: chimp, chimpanzee; rhesus, rhesus macaque; SNP, single nucleotide polymorphism. The SNPs from 1 to 8 are, respectively, rs1474605 (P1792), rs1018381 (P1578), rs2619522 (P1763), rs760761 (P1320), rs2005976 (P1757), rs2619528 (P1765), rs1011313 (P1325) and rs3213207 (P1635). Haplotypes 1 and 2 are the common and high-risk haplotypes in the ISHDSF. Haplotype frequencies were based on the ISHDSF study7 and the HapMap data (CEU, JPT+CHB and YRI). The sum of the haplotype frequencies is less than 1 because some other haplotypes were not included.