Fig. 7.
Space-filling structural models of fHbp based on the coordinates of the protein in a complex with a fragment of human fH (Schneider et al., 2009). The five variable segments VA to VE are depicted in different colours (VA, blue; VB, orange; VC, green; VD, light blue; VE, violet) and the invariant blocks of residues separating each of the variable segments are shown in white. The model in the middle was generated by rotation of 18 ° around the y axis relative to the respective model on the far left. The model on the right was generated by a 9 ° rotation around the x axis relative to the model in the middle. The fH contact residues are depicted in black, and the residues affecting the epitopes of anti-fHbp mAbs are shown in yellow. The figure was constructed with PyMol (http://www.pymol.org).