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. Author manuscript; available in PMC: 2011 Apr 6.
Published in final edited form as: J Pharm Biomed Anal. 2009 Nov 26;51(5):1120–1127. doi: 10.1016/j.jpba.2009.11.020

Fig. 7.

Fig. 7

Chromatograms of various CYP and UGT reaction substrates before and after incubation with rat liver microsomes for 1 h. The detector used was MS/MS and the methods were described in details in the Method section. (a) MRM chromatograms of testosterone after 1 h incubation in a CYP reaction system lacking NADPH (negative control); (b) MRM chromatograms of testosterone after 1 h incubation in a CYP reaction system; (c) MRM chromatograms of matrine after 1 h incubation in a CYP reaction system lacking NADPH (negative control); (d) MRM chromatograms of matrine after 1 h incubation in a CYP reaction system; (e) MRM chromatograms of genistein after 1 h incubation in a UGT reaction system lacking UDP-GA (negative control); (f) MRM chromatograms of genistein after 1 h incubation in a UGT reaction system; (g) MRM chromatograms of matrine after 1 h incubation in a UGT reaction system lacking UDP-GA (negative control); (h) MRM chromatograms of matrine after 1 h incubation in a UGT reaction system.