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Pharmacokinetic parameters of matrine in rat plasma (n = 4) after i.v. and oral administration of matrine.
| Parameter | i.v. | p.o. |
|---|---|---|
| Cmax (ng/ml) | – | 94.6 ± 38.6 |
| Tmax (min) | – | 105 ± 30 |
| AUC0–t (min ng/ml) | 108,637 ± 11,801 | 18,453 ± 5885 |
| AUC0–∞ (min ng/ml) | 108,794 ± 11,712 | 18,593 ± 5931 |
| t½ (min) | 142 ± 79 | 92 ± 32 |
| Ke (1/min) | 0.0060 ± 0.0030 | 0.0081 ± 0.0023 |
| V (ml/kg) | 3704 ± 1874 | 2433 ± 1668 |
| CL (ml/min/kg) | 18.6 ± 2.0 | 19.7 ± 5.5 |
| Bioavailability (%) | – | 17.1 ± 5.4 |
