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. Author manuscript; available in PMC: 2010 Apr 25.
Published in final edited form as: J Steroid Biochem Mol Biol. 2006 Dec 22;103(3-5):405–410. doi: 10.1016/j.jsbmb.2006.12.079

Fig. 3.

Fig. 3

SWI/SNF chromatin-remodeling complexes cooperate with VDR in the regulation of 24(OH)ase transcription. A. COS-7 cells were transfected with the same concentration of VDR (0.02 µg). Note the responsiveness of the 24(OH)ase promoter to 1,25(OH)2D3 is markedly reduced in the Brm andBrg-1 deficient cell lines SW13 and C33A. B. 1,25(OH)2D3 induced 24(OH)ase transcription can be restored by Brm. C. Inhibition of C/EBPβ enhancement of 24(OH)ase transcription. D. Immunoprecipitation (ip, Brm antibody; Western blot, C/EBPβ antibody) using MC3T3-E1 cells indicate that Brm can bind to C/EBPβ.