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. Author manuscript; available in PMC: 2010 Apr 25.
Published in final edited form as: J Cell Biochem. 2008 Oct 1;105(2):338–343. doi: 10.1002/jcb.21858

Figure 1.

Figure 1

Mechanism of repression of GM-CSF activated transcription by 1,25(OH)2D3. Unlike most mechanisms involved in 1,25(OH)2D3 mediated effects on transcription that require the VDR/RXR heterodimer, VDR bound to 1,25(OH)2D3 (VDRD3 in B) acts as a monomer on the GM-CSF promoter and competes with NFAT for binding to a composite NFAT AP1 site (composite site is shown in A). VDR bound to 1,25(OH)2D3 also stabilizes the binding of Fos-Jun heterodimer by direct interaction with cJun (B). These two events result in 1,25(OH)2D3 mediated transcriptional repression of GM-CSF (Adapted from Towers and Freedman, 1998)