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. 2010 Mar 26;6:17. doi: 10.1186/1746-6148-6-17

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Copyright ©2010 Rodríguez-Martínez et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Immunohistochemistry for PrP^Scusing a cocktail of mAb F89/160.1.5 and 2G11. A) Cerebellum of case M72 (100×) showing intense immunostaining in the molecular layer of cerebellar cortex. B) Frontal lobe of case M27 with F89/160.1.5/2G11, (400×) showing punctate globular immunostaining (arrow) in white matter. C) PrP^Scdeposits (arrowheads) in the granular layer of the cerebellum of case M27. Scant fine granular deposits of PrP^Scvisible in the granular layer (200×). D) Cerebellar cortex of case M15 with scant fine granular (arrowheads) deposits of PrP^Scvisible in the granular layer (400×). E) Cerebral cortex of case M15 (40×) showing fine granular immunolabelling following a laminar pattern.