Table 2.
Changes in echocardiographic parameters, blood pressure and biochemical variables associated with acute right ventricular overload
| Baseline | T = 2.5 hrs | T = 24 hrs | T = 72 hrs | ||
|---|---|---|---|---|---|
| RVED (mm) | Placebo | 41 ± 8 | 43 ± 8 | 42 ± 7 | 38 ± 5 |
| Epoprostenol | 41 ± 8 | 43 ± 7 | 38 ± 6 | 40 ± 9 | |
| Systolic PAP (mmHg) | Placebo | 47 ± 11 | 48 ± 17 | 41 ± 7 | 46 ± 9 |
| Epoprostenol | 57 ± 14 | 50 ± 19 | 55 ± 22 | 50 ± 14 | |
| TAPSE (cm) | Placebo | 2.0 ± 0.5 | 2.1 ± 0.6 | 2.3 ± 0.3 | 2.2 ± 0.6 |
| Epoprostenol | 1.9 ± 0.6 | 1.9 ± 0.5 | 2.0 ± 0.6 | 2.0 ± 0.5 | |
| RVFAC (%) | Placebo | 24 ± 18 | 28 ± 21 | 25 ± 17 | 29 ± 16 |
| Epoprostenol | 34 ± 24 | 34 ± 10 | 35 ± 16 | 33 ± 10 | |
| RAD (cm) | Placebo | 4.7 ± 0.7 | 4.4 ± 0.8 | 4.7 ± 1.3 | 4.3 ± 0.9 |
| Epoprostenol | 4.2 ± 0.9 | 4.6 ± 1.0 | 4.1 ± 1.2 | 4.1 ± 1.0 | |
| RV/LV | Placebo | 0.82 ± 0.16 | 0.88 ± 0.10 | 0.89 ± 0.15 | 0.69 ± 0.07 |
| Epoprostenol | 0.87 ± 0.24 | 0.97 ± 0.14 | 0.77 ± 0.23 | 0.79 ± 0.15 | |
| ABPs (mmHg) | Placebo | 117 ± 6 | 114 ± 12 | 118 ± 19 | 124 ± 11 |
| Epoprostenol | 125 ± 27 | 123 ± 26 | 118 ± 18 | 134 ± 29 | |
| ABPd (mmHg) | Placebo | 70 ± 10 | 71 ± 6 | 72 ± 12 | 74 ± 11 |
| Epoprostenol | 66 ± 14 | 70 ± 12 | 71 ± 11 | 72 ± 11 | |
| ABPm (mmHg) | Placebo | 86 ± 10 | 86 ± 7 | 87 ± 11 | 91 ± 10 |
| Epoprostenol | 82 ± 15 | 88 ± 6 | 87 ± 12 | 93 ± 12 | |
| CO (l/min) | Placebo | 6.2 ± 1.7 | 6.5 ± 0.6 | 6.7 ± 1.2 | 5.4 ± 1.2 |
| Epoprostenol | 5.5 ± 1.2 | 6.4 ± 1.1 | 5.9 ± 0.8 | 6.0 ± 0.8 | |
| NT-proBNP (pg/ml) | Placebo | 1467 (39-8549) | 925 (33-8322) | 694 (84-6954) | 343 (130-7240) |
| Epoprostenol | 3885 (270-12339) | 3043 (352-4811) | 3089 (415-4892) | 614 (147-4268) | |
| Troponin T (ng/ml) | Placebo | 0.01 (0.01-0.09) | 0.01 (0.01-0.09) | 0.01 (0.01-0.07) | 0.01 (0.01-0.04) |
| Epoprostenol | 0.03 (0.01-0.13) | 0.02 (0.01-0.12) | 0.01 (0.01-0.07) | 0.01 (0.01-0.08) |
Definition of abbreviations: PAP = pulmonary artery pressure; TAPSE = tricuspid annular plane systolic excursion; RVFAC = right ventricular fractional area change; RAD = right atrial end-diastolic diameter; RV/LV = right/left ventricular end-diastolic diameter; ABPs = systolic arterial blood pressure; ABPd = diastolic arterial blood pressure; ABPm = mean arterial blood pressure; RVED = right ventricular end-diastolic diameter;
Values are given as the mean ± SD. NT-proBNP and troponin T are given as median (range).
At no time point significant differences of these parameters between treatment groups were observed (P > 0.20). Data for NT-proBNP and Troponin T were log-transformed for statistical testing.