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. 2010 Mar 25;10:33. doi: 10.1186/1471-213X-10-33

Figure 1.

Figure 1

Positional cloning of the seven toes (7t) mutation. (A) Shown are the genotyping results for two affected animals (2554 and 3518, both showing polydactyly) harboring critical recombination events. This localized 7t to a 0.65 Mb interval between SSLP markers D9Mit154 and D9Mit99. (B) The intron/exon structure of Plzf on mouse chromosome 9. (C) Sequencing chromatograms of wild type (+/+) and Plzf7t/7t cDNA reveal an A to G change at nt 379 of the Plzf cDNA. (D) Schematic diagram of the PLZF proteins with the indicated BTB and zinc-finger (ovals with "Z") domains. The 7t mutation changes codon 44 from glutamic acid to glycine.