Table 2.
Comparison of Plzf-/- and Plzf7t/7t skeletal phenotypes
| Structure | Defect | Plzf-/- | Plzf7t/7t |
|---|---|---|---|
| Hindlimb | digit I>II transformation | 92% | 100% |
| preaxial digit resembles digit V or digit I absence | 40% | 20% | |
| Talus>calcaneus transformation | 90% | 53% | |
| interdigital webbing | 60% | 20% | |
| anterior C1 to navicular | 38% | ||
| C1 to cuboid bone | 42% | ||
| metatarsal fusion | 15% | 13% | |
| metatarsal bony outgrowths | 69% | 40% | |
| absent tibia | 98% | ||
| separation of tibia and fibula | 96% | 47% | |
| thickened fibula | 32% | 40% | |
| tibia to fibula transformation | 38% | 40% | |
| shortened zeugopod/absent fibula | 16% | 33% | |
| duplication or absence of patella | 52% | 0% | |
| absence of meniscus | 28% | 0% | |
| Forelimb | preaxial polydactyly | 5% | 0% |
| interdigital webbing | 5% | 0% | |
| Axial skeletal | 14 thoracic vertebrae | 100% | 0% |
| extra pair of ribs attached to sternum | 73% | ||
| malformed xiphoid process | 100% | 40% | |
| T10 to T11 vertebrae shift | 70% | n/a | |
| homeotic transformation of sacral region | 80% | 53% | |
| Shortening and kinked tail | 100% | 0% |