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. Author manuscript; available in PMC: 2010 Apr 26.
Published in final edited form as: Int J Neuropsychopharmacol. 2009 May 13;12(10):1395–1408. doi: 10.1017/S146114570900042X

Fig. 2.

Fig. 2

Effect of subchronic MK-801 administration on mRNA expression of NMDAR subunits in adult rat PFC tissue. (a–c) mRNA levels of NR1, NR2A, and NR2B subunits showed similar changes for different doses of MK-801 treatment. Both were significantly increased at very low doses of 0.01, 0.033 and 0.1 mg/kg, significantly decreased at a high dose of 1.0 mg/kg (p<0.05), and increased but not significantly at 0.33 mg/kg (p>0.05). (d, e) the mRNA levels of NR2C subunits were similar to the NR2B subunit except at 0.01 mg/kg, a dose at which the changes were not significant (p=0.095). (e) the mRNA change of NR2D was not significant at the high dose of 1.0 mg/kg (p=0.149), slightly different from other subunits (* p<0.05, ** p<0.01).