Table 1.

Transcripts for type I procollagen, collagen-processing enzymes, MMP-1, and TIMP-1 in Omniscan-treated fibroblasts.

Transcript	50 µM Omniscan	250 µM Omniscan
MMP-1	5.7 ± 0.9*	8.9 ± 0.8*
TIMP-1	2.1 ± 0.3*	2.5 ± 0.1*
Type I procollagen	No change	No change
Lysyl oxidase	No change	No change
Procollagen-N-propeptidase	No change	No change
Procollagen C-proteinase enhancer	No change	No change

Fibroblasts were incubated for 3 days in growth factor (EGF and insulin)-enriched, serum-free culture medium and treated with Omniscan. At the end of the incubation period, RNA was prepared and processed for RT-PCR as described in the Materials and Methods section. The results are presented as fold-change relative to the control and based on three independent assessments for each transcript.

^*indicates statistically significant increase compared to control at p<0.05 level.