Table 3.
Identification | Little mice (µM/L) | Wild-type mice (µM/L) | Mutant/wild-type ratio | P-value* |
---|---|---|---|---|
α-muricholic acid | 2274 | 588 | 3.9 | 0.013 |
β-muricholic acid | 3332 | 1952 | 1.7 | 0.177 |
Cholic acid | 19040 | 5180 | 3.7 | 0.005 |
Deoxycholic acid | 1965 | 1701 | 1.2 | 0.564 |
Iso-deoxycholic acid | 1816 | 3906 | 0.5 | 0.004 |
Oxodihydroxy bile acid | 3006 | 1688 | 1.8 | 0.005 |
Unidentified bile acid | 3482 | 2337 | 1.5 | 0.027 |
ω-muricholic acid | 3969 | 2980 | 1.3 | 0.211 |
Others | 7030 | 6194 | 1.1 | 0.401 |
Total | 45914 | 26525 | 1.7 | 0.015 |
The P-value refers to a Student’s t-test for the difference in bile acid levels between Little mice and wild-type controls as determined by gas chromatographymass spectrometry.