Table 4.

Serum bile acid levels in Little mice and wild-type mice

Identification	Little mice (µM/L)	Wild-type mice (µM/L)	Mutant/wild-type ratio	P-value*
Lithocholic acid	0.37	0.10	3.7	0.0006
Deoxycholic acid	1.39	0.38	3.7	0.0014
Chenodeoxycholic acid	2.03	0.40	5.1	0.0532
Cholic acid	3.56	1.03	3.5	0.0018
Ursodeoxycholic acid	2.79	0.99	2.8	< 0.0001
α-muricholic acid	0.00	0.09	0.0	0.0049
β-muricholic acid	10.28	1.90	5.4	0.0228
Total	20.42	4.89	4.18	0.0018

^*The P-value refers to a Student’s t-test for the difference in bile acid levels between Little mice and wild-type controls as determined by gas chromatographymass spectrometry.