Table 5.

Bile acid synthesis genes in Little mice

Gene	Description	Fold-change*	P-value†
Acox2	Acyl-coenzyme A oxidase 2	1.1	0.6167
Akr1d1	3-oxo-5-β-steroid 4-dehydrogenase	3.1	0.0057
Amacr	2-methylacyl-CoA racemase	0.8	0.5539
Baat	Bile acid coenzyme A: amino acid N-acyltransferase	1.2	0.0389
Ch25h	Cholesterol 25-hydroxylase	1.2	0.6596
Cyp27a1	Sterol 27-hydroxylase	0.7	0.0322
Cyp39a1	Cytochrome p450, 39a1	8.4	0.0010
Cyp46a1	Cholesterol 24-hydroxylase	0.8	0.5057
Cyp7a1	Cholesterol 7α-hydroxylase	0.5	0.2224
Cyp7b1	Oxysterol 7α-hydroxylase	0.04	< 0.0001
Cyp8b1	Sterol 12α-hydroxylase	0.7	0.2508
Dhrs9	3α-hydroxysteroid dehydrogenase	2.3	0.1061
Hsd17b4	D-bifunctional protein	1.5	0.1976
Scp2	Peroxisomal thiolase 2	0.5	0.0058
Slc27a5	Bile acid CoA ligase	1.6	0.0270

^*The fold-change refers to the ratio of the expression values of Little mice over the wild-type mice obtained by real-time PCR analysis.

^†The P-value refers to a Student’s t-test for the difference in expression between Little and wild-type mice.