Table 7.
CA treatment in wild-type mice up-regulates a largely overlapping set of detoxification metabolism genes as in Little mice
| Wildtype CA-treated mice |
|||
|---|---|---|---|
| Gene | Description | Fold-change* | P-value† |
| Abcb1a | ATP-binding cassette, subfamily B (MDR/TAP), member 1 A | 15.5 | < 0.0001 |
| Aldh1a1 | Aldehyde dehydrogenase family 1, subfamily A1 | 0.7 | 0.2099 |
| Cyp2a4 | Cytochrome p450, 2a4 | 5.1 | 0.0025 |
| Cyp2b10 | Cytochrome p450, 2b10 | 4.4 | 0.0047 |
| Cyp2b13 | Cytochrome p450, 2b13 | 31.9 | 0.0009 |
| Cyp2b9 | Cytochrome p450, 2b9 | 473.4 | < 0.0001 |
| Cyp2c38 | Cytochrome p450, 2c38 | 0.9 | 0.6353 |
| Cyp4a10 | Cytochrome p450, 4a10 | 5.1 | 0.0148 |
| Cyp4a14 | Cytochrome p450, 4a14 | 71.9 | 0.0001 |
| Cyt19 | Arsenite methyltransferase | 2.2 | 0.0749 |
| Fmo3 | Flavin containing monooxygenase 3 | 124.2 | 0.0001 |
| Fmo4 | Flavin containing monooxygenase 4 | 3.4 | 0.0091 |
| Gsta2 | Glutathione S-transferase, alpha 2 | 17.8 | < 0.0001 |
| Gsta4 | Glutathione S-transferase, alpha 4 | 9.1 | 0.0001 |
| Gstm2 | Glutathione S-transferase, mu 2 | 4.3 | 0.0091 |
| Gstm3 | Glutathione S-transferase, mu 3 | 36.2 | 0.0035 |
| Gsto2 | Glutathione transferase omega 2 | 0.5 | 0.0399 |
| Gstt2 | Glutathione S-transferase theta 2 | 4.6 | 0.0166 |
| Mgst3 | Microsomal glutathione S-transferase 3 | 9.7 | 0.0004 |
| mOAT6 | Solute carrier family 22 (organic anion transporter), member 20 | 8.4 | 0.0004 |
| Mt1 | Metallothionein 1 | 7.5 | 0.0090 |
| Papss2 | 3′-phosphoadenosine 5′-phosphosulfate synthase 2 | 2.4 | 0.0204 |
| Por | Cytochrome p450 reductase | 4.0 | 0.0007 |
| Slc21a5 | Solute carrier organic anion transporter family, member 1a5 | 9.9 | 0.0243 |
| Sth2 | Sulfotransferase family 2A, member 2 | 9.3 | 0.0007 |
| Sult1a1 | Sulfotransferase family 1A, phenol-preferring, member 1 | 4.4 | 0.0005 |
| Sult1d1 | Sulfotransferase family 1D, member 1 | 6.8 | 0.0292 |
| Sult1e1 | Sulfotransferase family 1E, member 1 | 5.8 | 0.0996 |
| Temt | Indolethylamine N-methyltransferase | 0.9 | 0.8868 |
| Ugt1a1 | UDP glucuronosyltransferase 1 family, polypeptide A1 | 4.1 | 0.1843 |
*
The fold-change refers to the ratio of the expression values of the CA-treated mice over the wild-type mice obtained by real-time PCR analysis.
†
The P-value refers to a Student’s t-test for the difference in expression between CA-treated mice and wild-type mice.