Table 8.

Selected genes involved in bile acid homeostasis

	Little mice		CA-treated wild-type mice		CA-treated Little mice		Fxr mice		Fxr/Little mice
Gene	Fold-change*	P-value†	Fold-change*	P-value†	Fold-change*	P-value†	Fold-change*	P-value†	Fold-change*	P-value†
Cyp7a1	0.5	0.2224	0.04	0.0016	0.01	0.0010	1.4	0.5168	2.6	0.1248
Cyp8b1	0.7	0.2508	0.004	0.0020	0.003	< 0.0001	2.1	0.0239	2.0	0.0454
Shp	0.7	0.3886	4.9	0.0073	3.9	0.0249	0.1	0.0008	0.01	0.0096
Slc21a1	0.002	< 0.0001	0.03	0.0036	0.004	< 0.0001	0.9	0.5462	0.002	0.0001
Slc21a5	5.7	0.0004	9.9	0.0243	5.9	0.0263	0.8	0.2927	2.6	0.0017
Bsep	1.1	0.8489	0.8	0.8252	0.7	0.5674	0.2	0.0011	0.05	0.0079
Ntcp	0.3	0.1089	0.2	0.0422	0.2	0.0855	0.1	0.0013	0.1	0.0014

^*The fold-change refers to the ratio of the expression values of each experimental group over the wild-type mice obtained by real-time PCR analysis.

^†The P-value refers to a Student’s t-test for the difference in expression between each experimental group and wild-type mice.