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. Author manuscript; available in PMC: 2011 Mar 12.
Published in final edited form as: Wound Repair Regen. 2010 Mar 12;18(2):223–234. doi: 10.1111/j.1524-475X.2010.00574.x

Figure 9.

Figure 9

Collagen lattice contraction in response to latent TGF-β1 and BB-94. Stressed-relaxed collagen lattices were used to determine contractile force generation. Latent TGF-β1 (10 ng/ml; open circle) could promote collagen contraction significantly greatly than no TGF-β1 (open diamond) (all times p<0.03) and to the same extent as active TGF-β1(1 ng/ml; closed square). Addition of BB-94 (5 μM) to latent TGF-β1 (10 ng/ml; closed triangle) significantly inhibited the promotion of collagen lattice contraction (all times **p≤0.01). All contraction assays were carried out in triplicate, and every experiment was repeated three or more times. Mean ± SEM.