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. 2010 Mar 1;285(18):13721–13735. doi: 10.1074/jbc.M109.063057

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FIGURE 7. — Western blot analysis of total and phosphorylated GSK-3α/β, total dual specificity tyrosine-phosphorylated and regulated kinase 1A (DYRK1A), β-catenin, GATA-4, NFATc3, and NFATc4 in WT and TEAD-1 Tg hearts. Total protein extracts (100 μg) obtained from 10-month-old WT and TEAD-1 Tg (line 12) hearts revealed no change in total GSK-3α/β and a significant decrease in phospho-GSK-3α/β (A). TEAD-1 Tg hearts displayed a significant increase in DYRK1A protein in total and nuclear extract (B and C) and decreases in nuclear β-catenin, GATA-4, NFATc3, and NFATc4 (D) (n = 5–8). GAPDH, glyceraldehyde-3-phosphate dehydrogenase.