TABLE 4.

Morphological and functional heart measurements

In vivo MRI heart functional measurements of 5- and 10-month-old TEAD-1 Tg (line 12) mice versus their wild-type littermates (n = 5) are shown. NS means not significant.

Morphological and functional remodeling of heart
	Wild type	TEAD-1 Tg	p value
5 months of age
End diastolic septal wall thickness	1.16 ± 0.11 mm	1.23 ± 0.22 mm	NS
Ejection fraction	66.20 ± 6.13%	71.80 ± 2.53%	NS
Stroke volume	39.28 ± 3.54 μl	42.32 ± 3.85 μl	NS
Cardiac output	13.77 ± 1.08 ml/min	12.69 ± 1.82 ml/min	NS
End systolic volume	20.25 ± 4.65 μl	16.60 ± 1.71 μl	NS
End diastolic volume	59.53 ± 5.27 μl	58.92 ± 4.46 μl	NS
Short axis fractional shortening	43.51 ± 4.10%	45.45 ± 3.88%	NS
Long axis fractional shortening	18.62 ± 5.52%	17.93 ± 6.50%	NS
10 months of age
End diastolic septal wall thickness	1.26 ± 0.10 mm	1.45 ± 0.14 mma	0.045
Ejection fraction	66.95 ± 3.55%	35.40 ± 15.06%b	0.0025
Stroke volume	58.89 ± 10.04 μl	33.07 ± 11.62 μlb	0.005
Cardiac output	25.56 ± 3.45 ml/min	11.56 ± 5.22 ml/minc	0.0002
End systolic volume	28.68 ± 1.38 μl	57.38 ± 21.46 μla	0.019
End diastolic volume	87.57 ± 10.16 μl	87.70 ± 21.50 μl	NS
Short axis fractional shortening	39.59 ± 6.30%	16.72 ± 10.25%b	0.004
Long axis fractional shortening	14.04 ± 3.95	8.40 ± 4.06	0.075

^a p < 0.05 versus WT.

^b p < 0.005.

^c p < 0.0005.