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. Author manuscript; available in PMC: 2010 Apr 26.
Published in final edited form as: Cancer Res. 2007 Oct 15;67(20):9713–9720. doi: 10.1158/0008-5472.CAN-07-2119

Figure 3.

Figure 3

Effect of CDK4 overexpression and CDK2 deletion on induced tumorigenesis in mouse skin. A. Percentage of mice with at least one papilloma (tumor incidence), within 40 weeks of the bi-weekly administration of 2.5 μg TPA. B. Average number of papillomas per mouse (tumor multiplicity) within 40 weeks of bi-weekly promotion with 2.5 μg TPA. C. Percentage of mice with squamous cell carcinomas (SCC incidence) within 40 weeks of bi-weekly promotion with 2.5 μg TPA. Wt (■), CDK2 (x), K5CDK4 (▲) and K5CDK4/CDK2−/− (●) mice.