Table 1.
Histopathological analysis of skin tumors
| Mice |
No of tumors/group |
No (%) of tumors classified as:* |
|||
|---|---|---|---|---|---|
| Papillomaa | SCC Ib | SCC IIc | SCC IIId | ||
| Wild type | 23 | 14 (60) | 9 (40) | 0 (0) | 0 (0) |
| CDK2−/− | 12 | 8 (66) | 4 (33) | 0 (0) | 0 (0) |
| K5CDK4 | 20 | 5 (25) | 9 (45) | 6 (25) | 1 (5) |
| K5CDK4/CDK2−/− | 14 | 8 (57) | 6 (43) | 0 (0) | 0 (0) |
χ2, p< 0.05.
a
No atypia in basal layers.
b
Well differentiated SCC, most of the tumor mass composed of differentiated cells.
c
Moderately differentiated with approximately 50% of differentiating cells.
d
Poorly differentiated tumor with little keratinization, approximately 10-25% of the tumor composed of differentiating cells.