Table 4.
Neurobehavioral Evaluation System-3 and PVT Outcomes by Beverage Condition
| NES3 Outcomes | N | Alcohol | Placebo | Difference (SD) |
Effect Size (d) |
P-value |
|---|---|---|---|---|---|---|
| Tests requiring speed | ||||||
| Finger Tapping Test: Mean number of taps, preferred hand (FTT-P) |
188 | 59.68 (7.11) |
60.12 (7.24) |
−0.44 (4.73) |
0.09 | NS |
| Sequences Test (ST-A-L) | ||||||
| Sequence A: Latency (ms)‡ |
188 | 14.35 (2.66) |
14.48 (3.02) |
−0.13 (2.59) |
0.05 | NS |
| Digit-Symbol Test (DST-L) | ||||||
| Latency (ms) § | 188 | 80.02 (9.53) |
79.53 (9.22) |
+0.49 (6.63) |
0.07 | NS |
| Pattern Memory Test (PMT-L) | ||||||
| Average response latency for correct items (seconds) |
188 | 3.17 (0.85) |
3.15 (0.90) |
+0.01 (0.71) |
0.02 | NS |
| Tests requiring sustained attention | ||||||
| Auditory digit span test (ADST-B)† | ||||||
| Maximum span backward | 188 | 6.25 (1.40) |
6.16 (1.42) |
+0.09 (1.40) |
0.06 | NS |
| Adaptive Paced Auditory Serial Addition Test (APASAT-C) | ||||||
| Number correct | 184 | 94.92 (3.42) |
95.06 (3.19) |
−0.14 (2.86) |
0.05 | NS |
| Visual Span Test (VST-B) | ||||||
| Maximum span backward | 186 | 5.41 (0.89) | 5.67 (1.16) | −0.26 (1.22) | 0.21 | 0.004 |
| Pattern Memory Test (PMT-C) | ||||||
| Number Correct | ||||||
| Male | 103 | 16.14 (2.90) |
16.06 (2.36) |
+0.08 (2.65) |
0.03 | NS |
| Female | 85 | 15.26 (2.74) |
16.12 (2.12) |
−0.86 (2.70) |
0.32 | 0.004 |
| Tests Requiring Sustained Attention and Reaction Time | ||||||
| Continuous Performance Test (CPT) | ||||||
| Reaction time (ms) | 187 | 378.77 (35.48) |
375.98 (35.82) |
+2.78 (22.47) |
0.12 | NS |
| Psychomotor Vigilance Test (PVT) | ||||||
| Median reaction time (ms) | 190 | 223.40 (22.81) |
218.57 (20.25) |
+4.83 (15.08) |
0.32 | 0.000 |
-All p-values are based on mixed effects models controlling for gender and session number.
-The interaction of gender and dose was tested in each model. If interaction found to be significant, results were presented by gender.
†
Valid range of span scores for the forward condition: 3–9; backward condition: 2–8.
‡
Maximum time permitted to complete Sequence A: 60 seconds; Sequence B: 120 seconds.
§
Maximum time permitted to complete digit/symbol test: 180 seconds.
¶
Estimated as the sum of the number of items answered correctly of those seen by the subject and 25% of the remaining number of items that the subject did not see due to early exit from the test.