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. Author manuscript; available in PMC: 2011 Apr 22.
Published in final edited form as: J Med Chem. 2010 Apr 22;53(8):3198–3213. doi: 10.1021/jm901839g

Scheme 1.

Scheme 1

Reagents and conditions: a: p-TsCl, pyr, DCM, 0 °C-r.t., 8 h;

b: N-Boc-2-aminoethanethiol, NaH, DMF, 0 °C-r.t., 8 h;

c: 70% AcOH, r.t., 12 h;

d: C15H31COCl, pyr, DMAP, DCM, 0 °C-r.t., 10 h;

e: TFA, r.t., 30 min;

f: Boc-L-Serine-OH, EDCI, EDIPA, DMAP, DCM, 0 °C-r.t., 8 h;

g: TFA, r.t., 30 min.