Table 3.
Significant proteins associated with different functional categories as shown in Figure 7.
| IPI reference | Gene symbol |
Protein name |
|---|---|---|
| Dopamine signaling | ||
| IPI00118022.1 | Ap2s1 | AP-2 complex subunit sigma-1 |
| IPI00131814.1 | Ddc | aromatic-l-amino-acid decarboxylase |
| IPI00377680.3 | Adcy2 | adenylate cyclase 2 |
| IPI00138131.1 | Th | tyrosine 3-monooxygenase |
| IPI00228978.2 | Cltb | clathrin light chain B |
| IPI00132410.1 | Rab5a | RAS-related protein |
| IPI00223800.4 | Pcbd1 | pterin-4-alpha-carbinolamine dehydratase |
| IPI00108318.1 | Ppp3cc | protein phosphatase 3 |
| IPI00343381.5 | Adcy5 | adenylate cyclase 5 |
| IPI00317759.4 | Ppp2r2b | protein phosphatase 2A |
| IPI00118723.3 | Ppp2r4 | serine/threonine-protein phosphatase |
| IPI00169711.1 | Maoa | amine oxidase A |
| IPI00226140.4 | Maob | amine oxidase B |
| IPI00224697.1 | Ppp2r5e | serine/threonine-protein phosphatase |
| IPI00119575.3 | Prkar1a | protein kinase |
| IPI00126719.1 | Ppp1r14a | protein phosphatase 1 |
| Mitochondria dysfunction | ||
| IPI00268145.4 | Atp12a | potassium-transporting atpase alpha chain |
| IPI00378485.2 | Atp1a4 | sodium/potassium-transporting atpase alpha-4 chain |
| IPI00123704.1 | Atp1b2 | sodium/potassium-transporting atpase subunit beta-2 |
| IPI00124221.1 | Atp1b3 | sodium/potassium-transporting atpase subunit beta-3 |
| IPI00378453.3 | Atp2b4 | ATP2B4 protein |
| IPI00313475.1 | Atp5c1 | ATP synthase gamma chain |
| IPI00313841.1 | Atp6v0d1 | vacuolar ATP synthase subunit D |
| IPI00118787.1 | Atp6v1d | vacuolar ATP synthase subunit D |
| IPI00315999.4 | Atp6v1f | vacuolar ATP synthase subunit F |
| IPI00121443.1 | Cox6a1 | cytochrome C oxidase, subunit VI A |
| IPI00131771.2 | Cox6c | cytochrome C oxidase polypeptide VIC |
| IPI00555023.1 | Gstp2 | glutathione S-transferase P 1 |
| IPI00672194.2 | LOC227112 | ATP synthase, H+ transporting, mitochondrial F0 complex |
| IPI00125460.1 | LOC674583 | ATP synthase coupling factor 6 |
| IPI00230715.4 | Ndufa13 | NADH dehydrogenase 1 alpha subunit 13 |
| IPI00315302.4 | Ndufa2 | NADH dehydrogenase 1 alphasubunit 2 |
| IPI00120212.1 | Ndufa9 | NADH dehydrogenase 1 alphasubunit 9 |
| IPI00132390.4 | Ndufb4 | NADH dehydrogenase 1 beta subunit 4 |
| IPI00132531.1 | Ndufb5 | NADH dehydrogenase 1 beta subunit 5 |
| IPI00133215.2 | Ndufb7 | NADH dehydrogenase 1 beta subunit 7 |
| IPI00387430.1 | Ndufb8 | NADH dehydrogenase 1 beta subunit 8 |
| IPI00128023.3 | Ndufs2 | NADH-ubiquinone oxidoreductase |
| IPI00120232.1 | Ndufs7 | NADH-ubiquinone oxidoreductase |
| IPI00130460.1 | Ndufv1 | NADH-ubiquinone oxidoreductase |
| IPI00132762.1 | Trap1 | heat shock protein 75 kDa |
| IPI00132347.1 | Uqcrb | ubiquinol-cytochrome C reductase binding protein |
| IPI00224210.4 | Uqcrq | ubiquinol-cytochrome C reductase |
| Apoptosis and cell death | ||
| IPI00123639.1 | Calr | calreticulin |
| IPI00555023.1 | Gstp2 | glutathione S-transferase P 1 |
| IPI00135475.2 | Dbn1 | drebrin |
| IPI00121013.1 | Pea15 | astrocytic phosphoprotein |
| IPI00278804.1 | Scamp1 | secretory carrier-associated membrane protein 1 |
| IPI00131720.3 | Cacnb4 | calcium channel subunit beta-4 |
| IPI00321942.4 | Arfip2 | arfaptin-2 |
| IPI00129191.1 | Nos1 | nitric-oxide synthase |
| IPI00114368.2 | Sec22b | vesicle-trafficking protein |
| IPI00116558.1 | Rhog | RHO-related GTP-binding protein |
| IPI00130840.6 | Cope | coatomer subunit epsilon |
| IPI00129577.1 | Pdcd8 | programmed cell death protein 8 |
| IPI00761930.1 | Prep | prolyl endopeptidase |
| IPI00227970.1 | Exoc7 | exocyst complex component 7 |
| IPI00121623.1 | Dynll1 | dynein light chain 1 |
| IPI00113517.1 | Ctsb | cathepsin B |
| IPI00111013.1 | Ctsd | cathepsin D |
| IPI00221613.4 | Arf1 | ADPribosylation factor 1 |
| IPI00127942.3 | Dstn | Destrin |
| IPI00112555.3 | Gars | glycyl-trna synthetase |
| IPI00130992.1 | Capns1 | calpain small subunit 1 |
| IPI00468140.2 | Sorbs1 | sorbin and sh3 domain-containing protein 1 |
| IPI00323483.3 | Pdcd6ip | programmed cell death 6-interacting protein |
| IPI00222557.4 | S100b | protein s100-b |
| IPI00466424.4 | Rab1 | member ras oncogene family |
| IPI00320420.3 | Clu | Clusterin |
| IPI00120193.1 | Cdc42 | cell division control protein 42 |
| IPI00125861.2 | Dlgh1 | disks large homolog 1 |
| IPI00125501.1 | Epb4.1l3 | band 4.1-like protein 3 |
| IPI00467383.2 | Cul3 | cullin-3 |
| IPI00125328.3 | Epb4.9 | Dematin |
| IPI00351827.5 | Shank3 | Shank3 |
| IPI00120345.1 | Gas7 | growth-arrest-specific protein 7 |
| IPI00270362.2 | Rapgef4 | RAP guanine nucleotide exchange factor 4 |
| IPI00125880.1 | Pacsin2 | protein kinase c and casein kinase substrate in neurons protein 2 |
| IPI00114380.1 | Gstm5 | glutathione S-transferase MU 5 |
| IPI00129685.1 | Tpt1 | translationally-controlled tumor protein |
| IPI00119663.2 | Mapk1 | mitogen-activated protein kinase 1 |
| IPI00420651.3 | Ppp1r9b | neurabin-2 |
| IPI00314153.4 | Yars | tyrosyl-trna synthetase |
| IPI00321734.6 | Glo1 | lactoylglutathione lyase |
| IPI00137227.1 | Rab2 | RAS-related protein |
| IPI00229703.5 | Vamp2 | vesicle-associated membrane protein |
| IPI00626662.2 | Aldh1a1 | retinal dehydrogenase 1 |
| IPI00469392.2 | Rtn4 | reticulon-4 |
| IPI00130589.7 | Sod1 | superoxide dismutase |
| IPI00321922.2 | Pacs1 | phosphofurin acidic cluster sorting protein 1 |
| IPI00750911.1 | Myo5a | Myo5a protein |
| IPI00130368.4 | LOC226472 | glutathione S-transferase, mu 4 |
| Calcium signaling | ||
| IPI00459570.1 | Tpm3 | tropomyosin 3, gamma |
| IPI00108318.1 | Ppp3cc | protein phosphatase 3 |
| IPI00278611.5 | Tpm3 | tropomyosin alpha-3 chain |
| IPI00313475.1 | Atp5c1 | ATP synthase gamma chain |
| IPI00132526.1 | Camk4 | calcium/calmodulin-dependent protein kinase type IV |
| IPI00338309.3 | Ryr2 | cardiac Ca2+ release channel |
| Ubiquitin system | ||
| IPI00402913.1 | Ube2v2 | ubiquitin-conjugating enzyme e2 variant 2 |
| IPI00378681.4 | Zubr1 | CG14472-PA |
| IPI00323130.3 | Tceb1 | transcription elongation factor B polypeptide 1 |
| IPI00108590.2 | LOC639383 | ubiquitin A-52 residue ribosomal protein |
| IPI00139518.3 | Ubb | ubiquitin B |
| IPI00128760.1 | Ube2l3 | ubiquitin-conjugating enzyme |
| IPI00165854.3 | Ube2n | ubiquitin-conjugating enzyme e2n |
| IPI00467383.2 | Cul3 | cullin-3 |
| IPI00108388.1 | Usp9x | ubiquitin carboxyl-terminal hydrolase FAF-x |
| IPI00462445.2 | Nedd4 | E3 ubiquitin-protein ligase |