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Basic scheme for cholesterol biosynthesis from radiolabeled acetate or mevalonate as precursors. The postulated mode of action of miltefosine on specific metabolic steps is included. Enzyme abbreviations: HMGCS1 (cytosolic HMG-CoA synthase); HMGCR (HMG-CoA reductase); FDPS (farnesyl diphosphate synthase); FDFT1 (farnesyl-diphosphate farnesyltransferase 1, also known as squalene synthase); LDLR (low-density lipoprotein receptor).
