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. 2010 Apr 19;4:17. doi: 10.3389/fnbeh.2010.00017

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Copyright © 2010 Gomi, Sassa, Thompson and Itohara.

This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.

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Morris water maze (MWM). (A) The escape latency (left) and swimming velocity (right) in each session of the hidden-platform test. There was a significant main effect in escape latency among trial sessions based on repeated measures ANOVA (F_(6,162) = 20.731, P < 0.001), but the main effect between genotypes was not significant (F_(1,27) = 2.465, P = 0.1281). There was a significant main effect between genotypes in the swimming velocity (F_(1,27) = 7.351, P = 0.0115). (B) Swimming profiles in the probe test. The percent quadrant search time (left), number of crossings over the platform position in the target quadrant (middle), percent time swimming along the pool-wall, and swimming velocity (right) were analyzed. Cdkl2^LacZ/LacZ mice crossed the platform position significantly less often than Cdkl2^+/+ mice. Significant main effects were detected among quadrants by ANOVA (F_(3,81) = 8.462, P < 0.0001) and between genotypes (F_(1,27) = 4.197, P = 0.0500). Significant differences in the percentage of the time swimming along the pool wall (t₍₂₇₎ = 3.379, P = 0.0022) and swimming velocity (t₍₂₇₎ = −3.068, P = 0.0049) were detected between genotypes by unpaired Student's t-test. (C) The escape latency (left) and swimming velocity (right) in each session of the visible-platform test. A significant main effect among trial sessions was detected by repeated measures ANOVA (F_(2,54) = 31.254, P < 0.0001), but there was no main effect between genotypes (F_(1,27) = 1.217, P = 0.2797). A significant main effect between genotypes was detected in the swimming velocity (F_(1,27) = 4.607, P = 0.0410).