Table 1.
Measurement of animal behavior in open field and elevated plus-maze.
| Genotype | Cdkl2+/+ | Cdkl2LacZ/LacZ | P | Cdkl2+/+ | Cdkl2LacZ/LacZ | P |
|---|---|---|---|---|---|---|
| Sex | Males | Females | ||||
| Number of animals | 29 | 23 | 15 | 15 | ||
| OPEN FIELD | ||||||
| Distance moved (cm) | ||||||
| 1st 1 min | 330 ± 24 | 359 ± 33 | 380 ± 57 | 322 ± 52 | ||
| 2nd 1 min | 378 ± 34 | 409 ± 36 | 385 ± 42 | 374 ± 48 | ||
| 3rd 1 min | 355 ± 34 | 399 ± 36 | 300 ± 35 | 383 ± 49 | ||
| Total 3 min | 1062 ± 81 | 1167 ± 89 | 1065 ± 109 | 1078 ± 111 | ||
| Time spent (s) | ||||||
| Corner | 109 ± 5 | 103 ± 6 | 102 ± 7 | 89 ± 7 | ||
| Side | 51 ± 3 | 55 ± 4 | 53 ± 6 | 65 ± 6 | ||
| Center | 20 ± 5 | 21 ± 4 | 26 ± 5 | 26 ± 9 | ||
| Rearing | 9.21 ± 1.21 | 13.26 ± 1.8 | 0.0607 | nc | nc | |
| Grooming | 0.75 ± 0.08 | 0.57 ± 0.11 | nc | nc | ||
| Feces | 0.79 ± 0.27 | 0.78 ± 0.27 | nc | nc | ||
| Urination | 0.18 ± 0.74 | 0.17 ± 0.81 | nc | nc | ||
| ELEVATED PLUS-MAZE | ||||||
| Open arm entry (no.) | 5.6 ± 0.8 | 7.0 ± 0.6 | 4.6 ± 0.9 | 6.8 ± 1.0 | ||
| Total entry (no.) | 10.9 ± 1.2 | 12.8 ± 1.0 | 10.7 ± 1.4 | 14.5 ± 2.0 | ||
| Open arm time (%) | 47.5 ± 4.3 | 53.2 ± 3.4 | 45.8 ± 6.9 | 46.4 ± 3.6 | ||
| Distance moved (cm) | 523 ± 44 | 611 ± 38 | 503 ± 40 | 622 ± 55 | 0.0972 | |
| Rearing | 4.79 ± 0.94 | 6.87 ± 1.11 | 2.86 ± 0.77 | 4.22 ± 1.11 | ||
| Head-dipping | 13.55 ± 1.57 | 12.91 ± 1.34 | 6.71 ± 1.32 | 10.11 ± 2.19 | ||
| Feces | 1.00 ± 0.11 | 1.13 ± 0.11 | 3.18 ± 0.62 | 1.83 ± 0.66 | ||
| Urination | 0.10 ± 0.06 | 0.13 ± 0.07 | 0.36 ± 0.19 | 0.41 ± 0.29 | ||
Blank space in P-value columns indicates P > 0.1 (unpaired Student's t-test). Data are presented as mean ± SEM; nc, not counted.