Table 1.
Comparison between the lesion profiles in the different immunosuppressive conditions.
| Lesions | Recruted Inflammatory Cells | Fungi | ||||||
|---|---|---|---|---|---|---|---|---|
| Proportion of inflammatory infiltrate surface | Major Localisation | Necrosis | Neutrophiles | Macrophages | Conidia | Hyphae | ||
| Chlodrolip |
Early 1 day PI |
1.8 ± 1.0% | Random distribution |
- | ++ | +/- | ++ | - |
|
Late 8 days PI |
2.9 ± 1.7% | Perivascular Peribronchiolar |
- | - | + | + | - | |
| Cortisone Acetate | ||||||||
|
Early 1 day PI |
3.8 ± 2.0% | Alveoli | ++ | ++ | +/- | ++ | +/- | |
|
Late 3 days PI |
11.2 ± 1.9% | Bronchi Bronchioles |
+++ | +++ | ++ | ++ | +++ | |
| RB6-8C5 | ||||||||
|
Early 1 day PI |
1.9 ± 0.5% | Random distribution |
+/- | - | +/- | + | - | |
|
Late 3 days PI |
18.9 ± 2.8% | Bronchi Bronchioles |
+++ | - | +++ | ++ | +++ | |
| Cyclophosphamide | ||||||||
|
Early 1 day PI |
No infiltrate | Bronchioles | +/- | +/- | - | +/- | - | |
|
Late 3 days PI |
No infiltrate | All structures | ++++ | - | - | + | ++++ | |
A group of five mice was studied at each time point, for each condition. The lesions were very similar between the different animals in a same group (PI: post-infection). A group of three mice was studied for the measurement of the surface of inflammatory cell infiltrates in tissue sections (morphometric analysis, 22 to 40 microscopic fields covering an entire lung section for each animal).
- none, +/- minimal, + mild, ++ moderate, +++ marked, ++++ severe