Table 1. Baseline characteristics of three patients failing on raltegravir-containing regimens.
Patient | VL | CD4 | Co-prescribed drugs | RT mutations | PR mutations | GSS |
1 | 6.7 | 16 | ETR/DRV/r | 41L 44D 67N 69D/N 74I 75T 101E 179F 181C 184V 190S 210W 215Y | 10F 15V 20R 32I 33F 36I 50V 54A 62V 63P 71V 84V 85V 89V 90M | 0 |
2 | 6.4 | 36 | ETR/DRV/r/ENF | 41L 44D 67N 74V 103N 184V 210W 215Y | 10F/V 15V 20R 33F 46I 62V 63P 71T 73S 76V 84V 89V 90M | 1 |
3 | 5.6 | 22 | TDF/FTC/ETR/DRV/r | 41L 44D 67N 70R 181C 184V 190A 210W 215Y | 10V 15V 20R 32I 33F 46I 54V 58E 63P 82A 84V 90M | 0 |
Abbreviations: VL: Viral load (Plasma HIV-1 RNA), log10copies/ml; CD4: CD4 (+) cell count (cells/µl); GSS: Genotypic sensitivity score;
TDF: tenofovir diphospho fumarate; ETR: etravirine; DRV/r: darunavir boosted with ritonavir; ENF: enfuvirtide; FTC: emtricitabine.