. Author manuscript; available in PMC: 2011 Jan 1.

Published in final edited form as: J Comb Chem. 2010 Jan–Feb;12(1):13–15. doi: 10.1021/cc900150d

Table 2.

Synthesis of 1,2,3-Triazole with Copper Turnings

no.	reagents^a	method	time(h)	yield(%)
15	A/B	oil bath	6	38
16		MW	3	21
17		US	2	88
18		MW/US	2	85
19	C/B	oil bath	6	34
20		MW	3	16
21		US	2	80
22		MW/US	2	86
23	D/E	oil bath	16	88
24		MW	3	41/37^b
25		US	2	81^c
26		MW/US	2	83^c
27	F/B	oil bath	10	64
28		MW	3	55
29		MW/US	2	80
31	G/B	oil bath	6	56
32		MW	3	68
33		US	2	81
34		MW/US	2	87

A) 1-azidoctane; B) phenylacetylene; C) 1-azidoheptadecane; D) benzylazide; E) 1,3-bis(propargyloxy)benzene; F) 6-monoazido-β-CD; G) 6-monoazido-permethyl-β-CD.

Ratio % mono- and bis-triazole derivatives.

% bis-triazole.