Table 1.

Relative changes in striatal metabolite concentrations between WT and R6/2 mice at 8 and 12 weeks of age and between different ages of the same strain

	% Change in R6/2 relative to WT		% Change at 12 weeks relative to 8 weeks
Metabolite	At 8 weeks	At 12 weeks	WT	R6/2
Mac	1	−2	−3	−6
Ala	−25		−15
Asc	16	62*	−21	10
Cr	38***	23**	3	−8
PCr	12	43***	0	28*
GPC	60***	206***	−13	66**
PCho	19	−3	33	8
GABA	−7	10	−15	0
Glc	33	−23	−2	−44*
Gln	41***	113***	−15	28**
Glu	−9	16**	−8	17**
GSH	36*	39**	8	10
myo-Ins	11	25***	−8	3
Lac	14	−23	−6	−36*
NAA	−16**	−22***	0	−8
NAAG	16	13	−6	−8
PE	−15	−22*	−3	−11
Tau	−2	36***	1	39**

Statistical comparisons were made using absolute metabolite concentrations (Fig. 2) and are repeated here for convenience. Significance level:

^*p < 0.01

^**p < 0.002

^***p < 0.0002.