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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: J Allergy Clin Immunol. 2009 Oct 8;125(1):160–9.e1-5. doi: 10.1016/j.jaci.2009.06.049

Figure 3. Topical LXR Ligand Normalizes Lamellar Body Secretion and Lamellar Bilayer Structure in Ox-AD Mice.

Figure 3

Stratum corneum of oxalozone (Ox) + vehicle (Veh)-treated skin sites demonstrate incomplete formation of lamellar bilayers (Panel A, open arrows and asterisks), while Ox + LXR ligand (TO; TO901317)-treated sites display both normal quantities of secreted lipid (Panel E) and normal organization of lamellar bilayers (Panels B&E, arrows). Decreased lamellar body secretion is indicated by paucity of lamellae at stratum granulosum (SG)-SC interface (Panel C, asterisks). As a result of decreased secretion, abundant lamellar body contents remain entombed in corneocytes (Panel D, arrows). A, B, D, E, ruthenium tetroxide post-fixation; C, osmium tetroxide post-fixative. Mag bars (A) = 0.2 μm (B) = 0.1 μm. (C) = 0.5 μm; (D) = 0.1 μm; (E) = 0.1 μm.