Table 1. Molecular and clinical features of the 22 MSS HNPCC patients.

Tumor location: R: right side of the colon including cecum, ascending colon, transverse colon up to splenic flexure. L: left side of the colon including descending colon and recto-sigmoid. wt: wild type. mut: mutated

	BRAF V600E	KRAS Codon 12	KRAS Codon 13	Gender	Tumor location	Amsterdam I or II	Age of the proband	Mean age of affected family members
1	wt	wt	wt	F	R	I	79	61
2	wt	mut	wt	F	L	II	89	60
3	wt	wt	wt	M	L	II	64	59
4	wt	wt	wt	M	R	I	49	51
5	wt	wt	wt	M	L	I	52	47
6	wt	wt	wt	M	L	I	47	67
7		mut	wt	M	L	I	50	63
8	wt	wt	wt	M	L	I	63	59
9	wt	mut	wt	M	L	I	55	53
10	wt	wt	wt	M	L	I	51	58
11	wt	mut	wt	M	L	I	73	49
12	wt	wt	wt	M	R	I	66	58
13	wt	wt	wt	M	L	I	52	54
14	wt	wt	wt	F	R	I	67	59
15	wt	wt	wt	M	L	I	48	59
16	wt	wt	wt	M	L	II	79	63
17	wt	wt	wt	F	L	II	80	62
18	wt	wt	wt	M		I	47	61
19	wt	mut	wt	F	L	I	54	52
20	wt	wt	wt	M	L	II	44	54
21	wt	mut	wt	M	L	I	38	57
22	wt	mut	wt	M	L	I	40	55