Table 1. Molecular and clinical features of the 22 MSS HNPCC patients.
Tumor location: R: right side of the colon including cecum, ascending colon, transverse colon up to splenic flexure. L: left side of the colon including descending colon and recto-sigmoid. wt: wild type. mut: mutated
BRAF V600E | KRAS Codon 12 | KRAS Codon 13 | Gender | Tumor location | Amsterdam I or II | Age of the proband | Mean age of affected family members | |
---|---|---|---|---|---|---|---|---|
1 | wt | wt | wt | F | R | I | 79 | 61 |
2 | wt | mut | wt | F | L | II | 89 | 60 |
3 | wt | wt | wt | M | L | II | 64 | 59 |
4 | wt | wt | wt | M | R | I | 49 | 51 |
5 | wt | wt | wt | M | L | I | 52 | 47 |
6 | wt | wt | wt | M | L | I | 47 | 67 |
7 | mut | wt | M | L | I | 50 | 63 | |
8 | wt | wt | wt | M | L | I | 63 | 59 |
9 | wt | mut | wt | M | L | I | 55 | 53 |
10 | wt | wt | wt | M | L | I | 51 | 58 |
11 | wt | mut | wt | M | L | I | 73 | 49 |
12 | wt | wt | wt | M | R | I | 66 | 58 |
13 | wt | wt | wt | M | L | I | 52 | 54 |
14 | wt | wt | wt | F | R | I | 67 | 59 |
15 | wt | wt | wt | M | L | I | 48 | 59 |
16 | wt | wt | wt | M | L | II | 79 | 63 |
17 | wt | wt | wt | F | L | II | 80 | 62 |
18 | wt | wt | wt | M | I | 47 | 61 | |
19 | wt | mut | wt | F | L | I | 54 | 52 |
20 | wt | wt | wt | M | L | II | 44 | 54 |
21 | wt | mut | wt | M | L | I | 38 | 57 |
22 | wt | mut | wt | M | L | I | 40 | 55 |